NICHD Study of Traumatic Brain Injury
Supported by National Institute of Child Health & Human Development Grant Number: R01 HD048946
Principal Investigator: Co-Principal Investigators:
|
About
The overall goal of this study is to examine the social outcomes of childhood traumatic brain injury (TBI). The study's specific aims are to: (1) characterize the social interactions and adjustment of children with TBI; (2) examine social information processing in children with TBI; (3) determine the integrity of brain regions and structures known to be vulnerable to TBI and implicated in social information processing; and (4) study the linkages among brain structures, social information processing, and social behavior and adjustment among children with TBI.
Overview of Study Design and Measures
The study used a cross-sectional, concurrent cohort design comparing 150 children with moderate to severe TBI to 150 children with orthopedic injuries (OI children) not involving the head. The OI group was chosen to assess the consequences of TBI relative to the consequences of trauma not involving the head, as well as to control for demographics and other factors associated with the risk of traumatic injury. Participants in both groups completed a series of assessments:
- Structural magnetic resonance imaging. Neuroimaging will enable volumetric and lesion analyses targeting the brain systems implicated in social information processing.
- Social cognition and Executive functions. We used existing measures of social-affective and cognitive-executive functions and social problem-solving, most of which are known to be sensitive to childhood TBI.
- Observations of peer interactions. We observed participants interacting with mutual friends, as well as with unfamiliar peers.
- Self-perceptions of social adjustment. The children and their mutual friends completed self-report measures of social self-esteem, loneliness, friendship and family relationship quality, and general adjustment.
- Classroom peer nominations. Peer nominations and ratings were obtained in the participants’ classrooms, to provide measures of peer acceptance, reciprocal friendship, and behavioral reputation (e.g., aggressiveness; anxious withdrawal; victimization; social competence; leadership).
- Teacher ratings. Teachers completed measures of behavioral reputation, social skills, and classroom adjustment.
- Parents ratings. Parents provided ratings of social skills and general adjustment at home.
- Measures of potential environmental moderators. Parents completed measures of socioeconomic status, family functioning, and parenting practices, which are variables that could act as risk or resilience factors in moderating the effects of TBI on social development.
Publications
Greer, K.M., Snyder, A., Junge, C., Reading, M., Jarvis, M. S., Squires, C., Bigler, E., Popuri, K., Beg, F., H., Taylor, H.G., Vannatta, K., Gerhardt, C., Rubin, K.H., Yeates, K.O. & Cobia, D. (2022). Surface-based abnormalities in frontostriatal circuitry relate to impaired executive functioning in pediatric TBI. Neuroimage (Clinical). https://doi.org/10.1016/j.nicl.2022.103136
Ryan, N.P., Anderson, V.A, Bigler, E.D., Dennis, M., Taylor, H.G., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., Beauchamp, M.H., Hearps, S., Catroppa, C., Yeates, K.O. (2021). Delineating the Nature and Correlates of Social Dysfunction after Childhood Traumatic Brain Injury Using Common Data Elements: Evidence from an International Multi-Cohort Study. Journal of Neurotrauma, 38 (2), 252-260. DOI: 10.1089/neu.2020.7057
Wright, K.L., Hopkins, R.O., Robertson, F., Bigler, E.D., Dennis, M., Taylor, H.G., Rubin, K., Vannatta, K., Stancin, T., & Yeates, K.O. (2020). Assessment of White Matter Integrity Following Pediatric Traumatic Brain Injury. Journal of Neurotrauma. 37, 2188-2197.
Hoskinson, K.R., Bigler, E.D., Abildskov, T.J., Dennis, M., Taylor, H.G., Rubin, K., Gerhardt, C.A., Vannatta, K., Stancin, T., & Yeates, K.O. (2019). The mentalizing network and theory of mind mediate adjustment after childhood traumatic brain injury. Social Cognitive and Affective Neuroscience, 14, 1285–1295
Deighton, S., Laliberté Durish, C., Taylor, G., Rubin, K.H., Dennis, M., Bigler, E., Vannatta, K., Gerhardt, C., Stancin. T., & Yeates. K.O.. (2019). Theory of mind and parental nurturance as predictors of peer relationships after childhood traumatic brain injury: A test of moderated mediation. Journal of the International Neuropsychological Society, 25, 931–940. DOI: 10.1017/S135561771900064X
Araujo, G.C., Antonini, T.A., Anderson, V., Vannatta, K.A., Salley, G., Bigler, E.D., Taylor, H.G., Gerhardt, C., Rubin, K., Dennis, M., Lo, W., Mackay, M., Yeates, K.O. (2017). Profiles of executive function across children with distinct brain disorders: Traumatic brain injury, stroke, and brain tumor. Journal of the International Neuropsychological Society, 23, 529-538. https://doi.org/10.1017/S1355617717000364
Meadows, E.A., Yeates, K.O., Rubin, K.H., Taylor, H.G., Bigler, E.D., Dennis, M., Gerhardt, C.A., Vannatta, K., Stancin, T., & Hoskinson, K.R. (2017). Rejection sensitivity as a moderator of psychosocial outcomes following pediatric traumatic brain injury. Journal of the International Neuropsychological Society, 23, 451-459. DOI:10.1017/S1355617717000352
Heverly-Fitt, S., Rubin, K.H., Dennis, M., Gerhardt, C.A., Vannatta, K., Taylor., H.G., Bigler, E.D., & Yeates, K.O. (2016). Investigating a proposed model of social competence in children with traumatic brain injuries. Journal of Pediatric Psychology. 41(2), 235-243. doi: 10.1093/jpepsy/jsv085
Root, A., Wimsatt, M.A., Rubin, K.H., Bigler, E.D., Dennis, M., Gerhardt, C., Stancin, T., Taylor, H.G., Vannatta, K., & Yeates, K.O. (2016). The parenting experiences of children with traumatic brain injury: Associations with social adjustment. Journal Applied Developmental Psychology, 42, 1-7. DOI: 10.1016/j.appdev.2015.10.002
Bigler, E.D., Hunsaker, N., Gale, S.D., Zielinski, B., Black, G.G., Huff, T., Christenson, Z., Wood, D.M., Abildskov, T., Dennis, M., Taylor, H.G., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., & Yeates, K.O. (2016). The relation of focal lesions to cortical thickness in pediatric traumatic brain injury. Journal of Child Neurology, 31, 1302-1311. DOI: 10.1177/0883073816654143
Shultz, E.L., Hoskinson, K.E., Keim, M.C., Dennis, M., Taylor, H.G., Bigler, E.D., Rubin, K., Vannatta, K., Gerhardt, C.A., Stancin, T., & Yeates, K.O. (2016). Adaptive functioning following pediatric traumatic brain injury: Relationship to executive function and processing speed. Neuropsychology, 30, 830-840 DOI: 10.1037/neu0000288
Wolfe, K.R., Bigler, E., Dennis, M., Gerhardt, C., Rubin, K.H., Taylor, H.G., Vannatta, K., & Yeates, K.O. (2015). Self-awareness of peer-rated social attributes in children with traumatic brain injury. Journal of Pediatric Psychology, 40, 272-284. DOI:10.1093/jpepsy/jsu060\
Bigler, E.D., Jantz, P.B., Farrer, T.J., Abildskov, T.J., Dennis, M., Gerhardt, C., Rubin, K.H., Stancin, T., Taylor, H.G., Vannatta, K., & Yeates, K.O. (2015). Day of Injury CT and Late MRI Findings and Cognitive Outcome in a Pediatric Sample with Complicated Mild Traumatic Brain Injury. Brain Injury, 29, 1062-1070. DOI: 10.3109/02699052.2015.1011234
Moran, L.M., Bigler, E., Dennis, M., Gerhardt, C. A., Rubin, K. H., Stancin, T., Taylor, H. G., Vannatta, K. A., & Yeates, K. O. (2015). Social problem solving and social adjustment in pediatric traumatic brain injury. Brain Injury, 29, 1682-1690. DOI: 10.3109/02699052.2015.1075140
Bigler, E., Black, G., Abildskov, T., Gerhardt, C., Rubin, K., Stancin, T., Vannatta, K., Taylor, H. G., & Yeates, K. O. (2015). Relation of cortical volume to intellectual function in pediatric traumatic brain injury. Archives of Clinical Neuropsychology, 30, 543-544.
Yeates, K., Bigler, E., Abildskov, T., Dennis, M, Gerhardt, C., Vannatta, K., Rubin, K.H., Stancin, T., & Taylor, H. G. (2014). Social competence in pediatric traumatic brain injury: From brain to behavior. Clinical Psychological Science, 2 (1) 97-107. DOI:10.1177/2167702613499734
Heverly-Fitt, S., Wimsatt, M.A., Menzer, M.M., Rubin, K.H., Dennis, M., Taylor., H.G., Stancin, T., Gerhardt, C.A., Vannatta, K., Bigler, E.D., & Yeates, K.O. (2014). Friendship quality and psychosocial outcomes among children with traumatic brain injury. Journal of the International Neuropsychological Society, 20(7), 684-93 DOI: 10.1017/S1355617714000393
Robinson, K.E., Fountain-Zaragoza, S., Dennis, M., Taylor, H.G., Bigler, E., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K.O. (2014). Yeates, K.O. (2014). Executive functions and theory of mind as predictors of social adjustment in childhood traumatic brain injury. Journal of Neurotrauma, 31, 1835–1842. DOI: 10.1089/neu.2014.3422
Dennis., M., Agostino, A., Taylor, H.G., Bigler, E.D., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., & Yeates, K.O. (2013). Emotional Expression and Socially Modulated Emotive Communication in Children after TBI. Journal of the International Neuropsychological Society. 19, 34–43. doi:10.1017/S1355617712000884
Dennis, M, Simic, N., Bigler, E., Abildskov, T., Agostino, A., Taylor, H. G., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K. (2013). Cognitive, affective, and conative theory of mind (ToM) in children with traumatic brain injury. Developmental Cognitive Neuroscience, 5, 25– 39. http://dx.doi.org/10.1016/j.dcn.2012.11.006
Yeates, K., Gerhardt, C., Bigler, E., Abildskov, T., Dennis, M, Rubin, K.H., Stancin, T., Taylor, H. G., & Vannatta, K., (2013). Peer relationships of children with traumatic brain injury. Journal of the International Neuropsychological Society, 19, 518–527. DOI:10.1017/S1355617712001531
Dennis, M, Simic, N., Agostino, A., Taylor, H. G., Bigler, E., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K. (2013). Irony and Empathy in Children with Traumatic Brain Injury. Journal of the International Neuropsychological Society, 19, 338–348. DOI:10.1017/S1355617712001440
Bigler, E.D., Abildskov, T.J, Petrie, J. A., Farrer, T.J., Dennis, M, Simic, N., Taylor, H. G., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K. (2013). Heterogeneity of brain lesions in pediatric traumatic brain injury. Neuropsychology, 27, 438–451. DOI: 10.1037/a0032837
Bigler, E. D., Yeates, K. O., Dennis, M., Gerhardt, C. A., Rubin, K. H., Stancin, T., Taylor, H. G., & Vannatta, K. (2013). Neuroimaging and social behavior in children after traumatic brain injury: Findings from the Social Outcomes of Brain Injury in Kids (SOBIK) study. NeuroRehabilitation, 32, 707-720. DOI: 10.3233/NRE-130896
Dennis., M., Simic, N., Taylor, H.G., Bigler, E.D., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., Roncadin, C, & Yeates, K.O. (2012). Theory of mind in children with traumatic brain injury. Journal of the International Neuropsychological Society, 18, 908-916. doi: 10.1017/S1355617712000756
Yeates, K.O., Bigler, E., Gerhardt, C.A., Rubin, K.H., Stancin, T., & Vannatta, K. (2012). Theoretical approaches to understanding social function in childhood brain insults: Toward the integration of social neuroscience and developmental psychology. In V. Anderson & M.H. Beauchamp (Eds.), Developmental social neuroscience and childhood brain insult: Implications for theory and practice. New York: Guilford.
Rubin, K.H., Schulz Begle, A., & McDonald, . (2012). Peer relations and social competence. In V. Anderson & M.H. Beauchamp (Eds.), Developmental social neuroscience and childhood brain insult: Implications for theory and practice. New York: Guilford.
Yeates, K.O., Bigler, E.D., Dennis, M., Gerhardt, C.A., Rubin, K.H., Stancin, T., Taylor, H.G., & Vannatta, K. (2007). Social Outcomes in Childhood Brain Disorder: Toward an Integrative, Multi-Level Model. Psychological Bulletin, 133, 535-556.
Greer, K.M., Snyder, A., Junge, C., Reading, M., Jarvis, M. S., Squires, C., Bigler, E., Popuri, K., Beg, F., H., Taylor, H.G., Vannatta, K., Gerhardt, C., Rubin, K.H., Yeates, K.O. & Cobia, D. (2022). Surface-based abnormalities in frontostriatal circuitry relate to impaired executive functioning in pediatric TBI. Neuroimage (Clinical). https://doi.org/10.1016/j.nicl.2022.103136
Ryan, N.P., Anderson, V.A, Bigler, E.D., Dennis, M., Taylor, H.G., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., Beauchamp, M.H., Hearps, S., Catroppa, C., Yeates, K.O. (2021). Delineating the Nature and Correlates of Social Dysfunction after Childhood Traumatic Brain Injury Using Common Data Elements: Evidence from an International Multi-Cohort Study. Journal of Neurotrauma, 38 (2), 252-260. DOI: 10.1089/neu.2020.7057
Wright, K.L., Hopkins, R.O., Robertson, F., Bigler, E.D., Dennis, M., Taylor, H.G., Rubin, K., Vannatta, K., Stancin, T., & Yeates, K.O. (2020). Assessment of White Matter Integrity Following Pediatric Traumatic Brain Injury. Journal of Neurotrauma. 37, 2188-2197.
Hoskinson, K.R., Bigler, E.D., Abildskov, T.J., Dennis, M., Taylor, H.G., Rubin, K., Gerhardt, C.A., Vannatta, K., Stancin, T., & Yeates, K.O. (2019). The mentalizing network and theory of mind mediate adjustment after childhood traumatic brain injury. Social Cognitive and Affective Neuroscience, 14, 1285–1295
Deighton, S., Laliberté Durish, C., Taylor, G., Rubin, K.H., Dennis, M., Bigler, E., Vannatta, K., Gerhardt, C., Stancin. T., & Yeates. K.O.. (2019). Theory of mind and parental nurturance as predictors of peer relationships after childhood traumatic brain injury: A test of moderated mediation. Journal of the International Neuropsychological Society, 25, 931–940. DOI: 10.1017/S135561771900064X
Araujo, G.C., Antonini, T.A., Anderson, V., Vannatta, K.A., Salley, G., Bigler, E.D., Taylor, H.G., Gerhardt, C., Rubin, K., Dennis, M., Lo, W., Mackay, M., Yeates, K.O. (2017). Profiles of executive function across children with distinct brain disorders: Traumatic brain injury, stroke, and brain tumor. Journal of the International Neuropsychological Society, 23, 529-538. https://doi.org/10.1017/S1355617717000364
Meadows, E.A., Yeates, K.O., Rubin, K.H., Taylor, H.G., Bigler, E.D., Dennis, M., Gerhardt, C.A., Vannatta, K., Stancin, T., & Hoskinson, K.R. (2017). Rejection sensitivity as a moderator of psychosocial outcomes following pediatric traumatic brain injury. Journal of the International Neuropsychological Society, 23, 451-459. DOI:10.1017/S1355617717000352
Heverly-Fitt, S., Rubin, K.H., Dennis, M., Gerhardt, C.A., Vannatta, K., Taylor., H.G., Bigler, E.D., & Yeates, K.O. (2016). Investigating a proposed model of social competence in children with traumatic brain injuries. Journal of Pediatric Psychology. 41(2), 235-243. doi: 10.1093/jpepsy/jsv085
Root, A., Wimsatt, M.A., Rubin, K.H., Bigler, E.D., Dennis, M., Gerhardt, C., Stancin, T., Taylor, H.G., Vannatta, K., & Yeates, K.O. (2016). The parenting experiences of children with traumatic brain injury: Associations with social adjustment. Journal Applied Developmental Psychology, 42, 1-7. DOI: 10.1016/j.appdev.2015.10.002
Bigler, E.D., Hunsaker, N., Gale, S.D., Zielinski, B., Black, G.G., Huff, T., Christenson, Z., Wood, D.M., Abildskov, T., Dennis, M., Taylor, H.G., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., & Yeates, K.O. (2016). The relation of focal lesions to cortical thickness in pediatric traumatic brain injury. Journal of Child Neurology, 31, 1302-1311. DOI: 10.1177/0883073816654143
Shultz, E.L., Hoskinson, K.E., Keim, M.C., Dennis, M., Taylor, H.G., Bigler, E.D., Rubin, K., Vannatta, K., Gerhardt, C.A., Stancin, T., & Yeates, K.O. (2016). Adaptive functioning following pediatric traumatic brain injury: Relationship to executive function and processing speed. Neuropsychology, 30, 830-840 DOI: 10.1037/neu0000288
Wolfe, K.R., Bigler, E., Dennis, M., Gerhardt, C., Rubin, K.H., Taylor, H.G., Vannatta, K., & Yeates, K.O. (2015). Self-awareness of peer-rated social attributes in children with traumatic brain injury. Journal of Pediatric Psychology, 40, 272-284. DOI:10.1093/jpepsy/jsu060\
Bigler, E.D., Jantz, P.B., Farrer, T.J., Abildskov, T.J., Dennis, M., Gerhardt, C., Rubin, K.H., Stancin, T., Taylor, H.G., Vannatta, K., & Yeates, K.O. (2015). Day of Injury CT and Late MRI Findings and Cognitive Outcome in a Pediatric Sample with Complicated Mild Traumatic Brain Injury. Brain Injury, 29, 1062-1070. DOI: 10.3109/02699052.2015.1011234
Moran, L.M., Bigler, E., Dennis, M., Gerhardt, C. A., Rubin, K. H., Stancin, T., Taylor, H. G., Vannatta, K. A., & Yeates, K. O. (2015). Social problem solving and social adjustment in pediatric traumatic brain injury. Brain Injury, 29, 1682-1690. DOI: 10.3109/02699052.2015.1075140
Bigler, E., Black, G., Abildskov, T., Gerhardt, C., Rubin, K., Stancin, T., Vannatta, K., Taylor, H. G., & Yeates, K. O. (2015). Relation of cortical volume to intellectual function in pediatric traumatic brain injury. Archives of Clinical Neuropsychology, 30, 543-544.
Yeates, K., Bigler, E., Abildskov, T., Dennis, M, Gerhardt, C., Vannatta, K., Rubin, K.H., Stancin, T., & Taylor, H. G. (2014). Social competence in pediatric traumatic brain injury: From brain to behavior. Clinical Psychological Science, 2 (1) 97-107. DOI:10.1177/2167702613499734
Heverly-Fitt, S., Wimsatt, M.A., Menzer, M.M., Rubin, K.H., Dennis, M., Taylor., H.G., Stancin, T., Gerhardt, C.A., Vannatta, K., Bigler, E.D., & Yeates, K.O. (2014). Friendship quality and psychosocial outcomes among children with traumatic brain injury. Journal of the International Neuropsychological Society, 20(7), 684-93 DOI: 10.1017/S1355617714000393
Robinson, K.E., Fountain-Zaragoza, S., Dennis, M., Taylor, H.G., Bigler, E., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K.O. (2014). Yeates, K.O. (2014). Executive functions and theory of mind as predictors of social adjustment in childhood traumatic brain injury. Journal of Neurotrauma, 31, 1835–1842. DOI: 10.1089/neu.2014.3422
Dennis., M., Agostino, A., Taylor, H.G., Bigler, E.D., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., & Yeates, K.O. (2013). Emotional Expression and Socially Modulated Emotive Communication in Children after TBI. Journal of the International Neuropsychological Society. 19, 34–43. doi:10.1017/S1355617712000884
Dennis, M, Simic, N., Bigler, E., Abildskov, T., Agostino, A., Taylor, H. G., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K. (2013). Cognitive, affective, and conative theory of mind (ToM) in children with traumatic brain injury. Developmental Cognitive Neuroscience, 5, 25– 39. http://dx.doi.org/10.1016/j.dcn.2012.11.006
Yeates, K., Gerhardt, C., Bigler, E., Abildskov, T., Dennis, M, Rubin, K.H., Stancin, T., Taylor, H. G., & Vannatta, K., (2013). Peer relationships of children with traumatic brain injury. Journal of the International Neuropsychological Society, 19, 518–527. DOI:10.1017/S1355617712001531
Dennis, M, Simic, N., Agostino, A., Taylor, H. G., Bigler, E., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K. (2013). Irony and Empathy in Children with Traumatic Brain Injury. Journal of the International Neuropsychological Society, 19, 338–348. DOI:10.1017/S1355617712001440
Bigler, E.D., Abildskov, T.J, Petrie, J. A., Farrer, T.J., Dennis, M, Simic, N., Taylor, H. G., Rubin, K.H., Vannatta, K., Gerhardt, C., Stancin, T., & Yeates, K. (2013). Heterogeneity of brain lesions in pediatric traumatic brain injury. Neuropsychology, 27, 438–451. DOI: 10.1037/a0032837
Bigler, E. D., Yeates, K. O., Dennis, M., Gerhardt, C. A., Rubin, K. H., Stancin, T., Taylor, H. G., & Vannatta, K. (2013). Neuroimaging and social behavior in children after traumatic brain injury: Findings from the Social Outcomes of Brain Injury in Kids (SOBIK) study. NeuroRehabilitation, 32, 707-720. DOI: 10.3233/NRE-130896
Dennis., M., Simic, N., Taylor, H.G., Bigler, E.D., Rubin, K.H., Vannatta, K., Gerhardt, C.A., Stancin, T., Roncadin, C, & Yeates, K.O. (2012). Theory of mind in children with traumatic brain injury. Journal of the International Neuropsychological Society, 18, 908-916. doi: 10.1017/S1355617712000756
Yeates, K.O., Bigler, E., Gerhardt, C.A., Rubin, K.H., Stancin, T., & Vannatta, K. (2012). Theoretical approaches to understanding social function in childhood brain insults: Toward the integration of social neuroscience and developmental psychology. In V. Anderson & M.H. Beauchamp (Eds.), Developmental social neuroscience and childhood brain insult: Implications for theory and practice. New York: Guilford.
Rubin, K.H., Schulz Begle, A., & McDonald, . (2012). Peer relations and social competence. In V. Anderson & M.H. Beauchamp (Eds.), Developmental social neuroscience and childhood brain insult: Implications for theory and practice. New York: Guilford.
Yeates, K.O., Bigler, E.D., Dennis, M., Gerhardt, C.A., Rubin, K.H., Stancin, T., Taylor, H.G., & Vannatta, K. (2007). Social Outcomes in Childhood Brain Disorder: Toward an Integrative, Multi-Level Model. Psychological Bulletin, 133, 535-556.